Steroidogenic factor-1 hypermethylation in maternal rat blood could serve as a biomarker for intrauterine growth retardation
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Steroidogenic factor-1 hypermethylation in maternal rat blood could serve as a biomarker for intrauterine growth retardation
Intrauterine growth retardation (IUGR) is a common obstetric complication lacking an optimal method for prenatal screening. DNA methylation profile in maternal blood holds significant promise for prenatal screening. Here, we aimed to screen out potential IUGR biomarkers in maternal blood from the perspective of DNA methylation. The IUGR rat model was established by prenatal maternal undernutrit...
متن کاملIntrauterine growth retardation.
The recognition that some low birthweight babies (<2500 g) were the victims of intrauterine growth retardation rather than premature birth was a milestone in perinatal medicine.'3 Up to 10% of all liveborn babies and at least 30% of those of low birth weight suffer from intrauterine growth retardation; their perinatal mortality is four to 10 times higher than that of normally grown babies-both ...
متن کامل[Energy intake, maternal nutritional status and intrauterine growth retardation].
To explore the association between low caloric intake during pregnancy and intrauterine growth retardation (IUGR), a case-control study with 264 cases and 892 controls was conducted in three maternity hospitals in Mexico City from January to August 1995. Nutritional information on pregnancy was recorded using a previously validated food frequency questionnaire. After adjusting for other known m...
متن کاملEffect of maternal hyperalimentation on intrauterine growth retardation.
The effect of maternal hyperalimentation on intrauterine growth retardation was studied by performing unilateral uterine vessel ligation on day 17 in Wistar rats. Test animals were given food supplements by gavage for three days postoperatively whereas control animals received saline. The caloric intake and weight gain of the test dams was significantly greater than that of the controls from da...
متن کاملIntrauterine Growth Retardation
Intrauterine growth retardation (IUGR) refers to fetal growth that has been constrained in utero. It results in newborns that have not attained their full growth potential and are already malnourished at birth. Fetuses that suffer from growth retardation have higher perinatal morbidity and mortality and are more likely to experience poor cognitive development and neurologic impairment during ch...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.21767