Stigmasterol stimulates neuronal migration through Reln-ApoER2-JNK signaling in neurosphere migration assays
نویسندگان
چکیده
منابع مشابه
Hippo signaling promotes JNK-dependent cell migration.
Overwhelming studies show that dysregulation of the Hippo pathway is positively correlated with cell proliferation, growth, and tumorigenesis. Paradoxically, the detailed molecular roles of the Hippo pathway in cell invasion remain debatable. Using a Drosophila invasion model in wing epithelium, we show herein that activated Hippo signaling promotes cell invasion and epithelial-mesenchymal tran...
متن کاملGlutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration.
During cortical development, embryonic neurons migrate from germinal zones near the ventricle into the cortical plate, where they organize into layers. Mechanisms that direct neuronal migration may include molecules that act as chemoattractants. In rats, GABA, which localizes near the target destination for migrating cortical neurons, stimulates embryonic neuronal migration in vitro. In mice, g...
متن کاملThrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.
Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway. Postnatal migration of neuronal precursors from the subventricular zone (SVZ) to the olfactory bulb (OB), however, depends on ApoER2 and Dab1, but functions independent...
متن کاملNeuronal Migration
ENCYCLOPEDIA OF LIFE SCIENCES July 2002 ©Macmillan Reference Ltd Neuronal Migration Introductory Structures and Processes Developmental Biology Author to provide list of keywords Wong, Kit Kit Wong Washington University School of Medicine, St. Louis, Missouri, USA Wu, Jane Y Jane Y Wu Washington University School of Medicine, St. Louis, Missouri, USA Rao, Yi Yi Rao Washington University School ...
متن کاملNeuronal migration
Like other motile cells, neurons migrate in three schematic steps, namely leading edge extension, nuclear translocation or nucleokinesis, and retraction of the trailing process. In addition, neurons are ordered into architectonic patterns at the end of migration. Leading edge extension can proceed at the extremity of the axon, by growth cone formation, or from the dendrites, by formation of den...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.1497