Strategies to functionalize extracellular vesicles against HER2 for anticancer activity

Cell-secreted extracellular vesicles (EVs) are membranous particles highly heterogeneous in size and molecular cargo. Comprehensively, released EV sub-populations can show a wide range selection of different protein, RNA, lipid species, complementing cell communication signals. Recently, EVs represent new source for developing targeted delivery systems. stable biofluids, intrinsically biocompatible with low immunogenicity, capable transferring cargo molecules into “recipient” cells. The immune-mediated recognition represents popular approach to functionalize direct towards receptor-positive populations. human epidermal growth factor receptor 2 (HER2, also known as neu or ERBB2) is tyrosine kinase clinical relevance, by several available antibodies, model used test the biodistribution anticancer activity bioformulations, including EVs. Here, we focus on recent strategies adopted functionalization fusion ligands able recognize HER2, covering enhanced expression membrane-fusion proteins “EV-donor” cells well post-isolation EV-surface modifications.