Strategies to transform remote C(sp3)-H bonds of amino acid derivatives

Amino acids and peptides play an important role in nature as well the pharmaceutical industry. Therefore, transformation of amino into their unnatural derivatives via step atom economical ways is highly demanding. Although, a number methods exist for selective reactions proximal α- or β-C(sp3)-H bond, functionalization distal bonds remains challenge. In recent years, transition metal catalyzed C–H has come up superior tool bond transformations. this review, we intend to provide reader detailed overview current state art utilization site technology peptides. Various synthetic tools have been discussed deliver broader idea about field. A systematic compilation presented here insights developments future challenges