Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
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چکیده
منابع مشابه
Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF-κB. In this study, we established a stable expression system for recombinant UbcH5c and solved t...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2017
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2016.12.008