Structural and Activity Profile Relationships Between Drug Scaffolds
نویسندگان
چکیده
منابع مشابه
Relationships between Molecular Complexity, Biological Activity, and Structural Diversity
Following the theoretical model by Hann et al. moderately complex structures are preferable lead compounds since they lead to specific binding events involving the complete ligand molecule. To make this concept usable in practice for library design, we studied several complexity measures on the biological activity of ligand molecules. We applied the historical IC50/EC50 summary data of 160 assa...
متن کاملon translation of phatic communion and socio-cultural relationships between the characters of the novels
phatic communion is a cultural concept which differs across cultures. according to hofstede (2001), the u.s. tends to have individualistic culture; however, asian countries tend to have collectivistic cultures. these cultures view phatic communion differently. in individualistic cultures like u.s., phatic communion reflects speakers’ socio-cultural relationships in conversations. to see whether...
15 صفحه اولStructural Relationships between Assertiveness and Parenting Styles with Mediating Self-Esteem and Anxiety of Singleton Children
Objectives: This study aimed to develop an explanatory model of assertiveness based on parenting styles mediated by anxiety and self-esteem. Methods: This study is descriptive-correlational modeling with partial least squares. The statistical population included singleton children of the sixth grade of the elementary school in the 3rd District of Tehran in the academic year 2017-18. The sampli...
متن کاملStructural Antitumoral Activity Relationships of Synthetic Chalcones
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, sug...
متن کاملModeling Structural Relationships Between Epistemological Beliefs and Mediating Learning Strategies on Anxiety in English Students
Introduction :The purpose of this study was to investigate the modeling of modeling structural relationships between epistemological beliefs and mediating learning strategies on the English language anxiety of third-year high school girl students in Babol. Methods:Correlation research was based on structural equation modeling. The statistical population consisted of 3rd grade high school girl s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2015
ISSN: 1550-7416
DOI: 10.1208/s12248-015-9737-5