Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus
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چکیده
منابع مشابه
Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrophobic export apparatus components SpaP and SpaR were shown to nucleate assembl...
متن کاملFunctional Activation of the Flagellar Type III Secretion Export Apparatus
Flagella are assembled sequentially from the inside-out with morphogenetic checkpoints that enforce the temporal order of subunit addition. Here we show that flagellar basal bodies fail to proceed to hook assembly at high frequency in the absence of the monotopic protein SwrB of Bacillus subtilis. Genetic suppressor analysis indicates that SwrB activates the flagellar type III secretion export ...
متن کاملOrganization and coordinated assembly of the type III secretion export apparatus.
Type III protein secretion systems are unique bacterial nanomachines with the capacity to deliver bacterial effector proteins into eukaryotic cells. These systems are critical to the biology of many pathogenic or symbiotic bacteria for insects, plants, animals, and humans. Essential components of these systems are multiprotein envelope-associated organelles known as the needle complex and a gro...
متن کاملInteraction between FliJ and FlhA, components of the bacterial flagellar type III export apparatus.
A soluble protein, FliJ, along with a membrane protein, FlhA, plays a role in the energy coupling mechanism for bacterial flagellar protein export. The water-soluble FliH(X)-FliI(6) ATPase ring complex allows FliJ to efficiently interact with FlhA. However, the FlhA binding site of FliJ remains unknown. Here, we carried out genetic analysis of a region formed by well-conserved residues-Gln38, L...
متن کاملInteraction between FliJ and FlhA , components of the 1 bacterial flagellar type III export apparatus
1 Interaction between FliJ and FlhA, components of the 1 bacterial flagellar type III export apparatus 2 3 Tatsuya Ibuki, Yumiko Uchida, Yusuke Hironaka, Keiichi 4 Namba, Katsumi Imada, and Tohru Minamino 5 6 a Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan 7 b Department of Macromolecular Science, Graduate School of Science, Osaka 8 University, 1-1 Machikaneyama...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2016
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1006071