Structural and Functional Studies Indicate That the EPEC Effector, EspG, Directly Binds p21-Activated Kinase
نویسندگان
چکیده
منابع مشابه
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.
Kinases are important therapeutic targets in oncology due to their frequent deregulation in cancer. Typical ATP-competitive kinase inhibitors, however, also inhibit off-target kinases that could lead to drug toxicity. Allosteric inhibitors represent an alternative approach to achieve greater kinase selectivity, although examples of such compounds are few. Here, we elucidate the mechanism of act...
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confirm that the work presented in this thesis is my own. Where information has been derived from other sources, I confirm that this has been indicated in the thesis I have not submitted any portion of the work referred to in this thesis in support of any other qualification at this or any other institute of higher learning Abstract AMP-activated protein kinase (AMPK) is an enzyme that senses a...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2011
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi1020138