Structural and Thermodynamics Studies on Polyaminophosphonate Ligands for Uranyl Decorporation

The development of actinide decorporation agents with high complexation affinity, tissue specificity, and low biological toxicity is vital importance for the sustained healthy nuclear energy. After accidental intake, sequestration by chelation therapy to reduce acute damage considered as most effective method. In this work, a series bis- tetra-phosphonated pyridine ligands have been designed, synthesized, characterized uranyl (UO22+) decorporation. Owing absorption ligand luminescence ion, UV–vis spectroscopy time-resolved laser-induced fluorescence (TRLFS) were used probe in situ structure variation complexes formed uranyl. Density functional theory (DFT) calculations X-ray fine (XAFS) on uranyl–ligand revealed coordination geometry around center at pH 3 7.4. High affinity constants (log K ∼17) toward ion determined displacement titration. A preliminary vitro study proves that bis-phosphonated can remove uranium from calmodulin (CaM) dose short term, which supports further applications these ligands.