Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain
نویسندگان
چکیده
منابع مشابه
Molecular basis of Wnt activation via the DIX domain protein Ccd1.
The Wnt signaling plays pivotal roles in embryogenesis and cancer, and the three DIX domain-containing proteins, Dvl, Axin, and Ccd1, play distinct roles in the initiation and regulation of canonical Wnt signaling. Overexpressed Dvl has a tendency to form large polymers in a cytoplasmic punctate pattern, whereas the biologically active Dvl in fact forms low molecular weight oligomers. The molec...
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Ccd1, a Novel Protein with a DIX Domain, Is a Positive Regulator in the Wnt Signaling during Zebrafish Neural Patterning
Wnt signaling plays a crucial role in directing cell differentiation, polarity, and growth. In the canonical pathway, Wnt receptors activate Dishevelled (Dvl), which then blocks the degradation of a key signal transducer, beta-catenin, leading to the nuclear accumulation of beta-catenin and induction of Wnt target genes through TCF/LEF family transcription factors. Here we identified a novel ze...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-08019-5