Structural Requirements for Cooperativity in Ileal Bile Acid-binding Proteins
نویسندگان
چکیده
منابع مشابه
Structure-cooperativity relationship in ileal bile acid binding proteins
Background: Ileal bile acid binding proteins display different degrees of binding cooperativity. Results: The structure of a low cooperative protein complexed with bile salts was determined. The protein was mutated to enhance its cooperativity. Conclusion: The cooperative binding requires few latch residues that stabilize an H-bond network. Significance: Knowledge of the determinants of coopera...
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Members of the GCM family of transcription factors contain a DNA binding domain unrelated to any other known DNA binding domain and bind to a DNA sequence motif not recognized by any other known transcription factor. Here we show that positions 2, 3, 6 and 7 of the 5'-ATGCGGGT-3' motif are particularly important for DNA binding and that methylation of several G residues on the upper strand, but...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.261099