Structural requirements for palmitoylation of surfactant protein C precursor

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Structural requirements for palmitoylation of surfactant protein C precursor.

Pulmonary surfactant protein C (SP-C) propeptide (proSP-C) is a type II transmembrane protein that is palmitoylated on two cysteines adjacent to its transmembrane domain. To study the structural requirements for palmitoylation of proSP-C, His-tagged human proSP-C and mutant forms were expressed in Chinese hamster ovary cells and analysed by metabolic labelling with [3H]palmitate. Mutations were...

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Palmitoylation of pulmonary surfactant protein SP-C is critical for its functional cooperation with SP-B to sustain compression/expansion dynamics in cholesterol-containing surfactant films.

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 2002

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj3610663