Structural Requirements of Cholesterol for Binding toVibrio choleraeHemolysin
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Structural requirements for DNA binding of GCM proteins.
Members of the GCM family of transcription factors contain a DNA binding domain unrelated to any other known DNA binding domain and bind to a DNA sequence motif not recognized by any other known transcription factor. Here we show that positions 2, 3, 6 and 7 of the 5'-ATGCGGGT-3' motif are particularly important for DNA binding and that methylation of several G residues on the upper strand, but...
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Animal and human tissues contain a microsomal protein that binds nonsteroidal antiestrogens with high affinity and specificity. The functions of these binding sites and the identity of their natural ligands are unknown. Following a report that certain sterols inhibit [3H]tamoxifen binding to this site, we attempted to define the structural requirements for maximal inhibition of [3H]tamoxifen bi...
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The class II antigens ofthe human MHC are cell surface heterodimers composed of noncovalently linked 35-kD a chains and 29-kD (3 chains . These antigens are present on macrophages, B lymphocytes, and other APC (for review, see reference 1). Class II antigens are capable of binding immunogenic peptides and thereby serve as ligand for the TCR (2, 3) . Recent experiments have demonstrated that cla...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2006
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.2006.tb03848.x