Structural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels
نویسندگان
چکیده
منابع مشابه
Structural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels.
Cyclic nucleotide-binding domains (CNBDs) that are present in various channel proteins play crucial roles in signal amplification cascades. Although atomic resolution structures of some of those CNBDs are available, the detailed mechanism by which they confer cyclic nucleotide-binding to the ion channel pore remains poorly understood. In this review, we describe structural insights about cyclic...
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abs t rac t Middendorf et al. (Middendorf, T.R., R.W. Aldrich, and D.A. Baylor. 2000. J. Gen. Physiol. 116:227– 252) showed that ultraviolet light decreases the current through cloned cyclic nucleotide–gated channels from bovine retina activated by high concentrations of cGMP. Here we probe the mechanism of the current reduction. The channels’ open probability before irradiation, P o (0), deter...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 2013
ISSN: 1437-4315,1431-6730
DOI: 10.1515/hsz-2013-0228