Structural Stability of Streptococcal Serum Opacity Factor
نویسندگان
چکیده
منابع مشابه
The contribution of serum opacity factor to group A streptococcal epithelial cell invasion
Serum opacity factor (SOF) is a bifunctional cell surface protein expressed by 40–50% of group A streptococcal (GAS) strains comprised of a C-terminal domain that binds fibronectin and an N-terminal domain that mediates opacification of mammalian sera. SOF is co-transcribed in a twogene operon with another fibronectin-binding protein, SfbX. We compared the ability of an SOF(+) wild-type (WT) se...
متن کاملSerum opacity factor promotes group A streptococcal epithelial cell invasion and virulence.
Serum opacity factor (SOF) is a bifunctional cell surface protein expressed by 40-50% of group A streptococcal (GAS) strains comprised of a C-terminal domain that binds fibronectin and an N-terminal domain that mediates opacification of mammalian sera. The sof gene was recently discovered to be cotranscribed in a two-gene operon with a gene encoding another fibronectin-binding protein, sfbX. We...
متن کاملSerum opacity factor of Staphylococcus epidermidis.
Three Staphylococcus epidermidis strains produced a factor giving rise to opacity in different sera but not in albumin. Serum opacity factor was resistant to age and heat and active in acidic media.
متن کاملThe Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins
Serum opacity factor (SOF) is a virulence determinant expressed by a variety of streptococcal and staphylococcal species including both human and animal pathogens. SOF derives its name from its ability to opacify serum where it targets and disrupts the structure of high-density lipoproteins resulting in formation of large lipid vesicles that cause the serum to become cloudy. SOF is a multifunct...
متن کاملOpacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete.
Serum opacity factor (SOF) is a unique multifunctional virulence determinant expressed at the surface of Streptococcus pyogenes and has been shown to elicit protective immunity against GAS infection in a murine challenge model. SOF consists of two distinct domains with different binding capacities: an N-terminal domain that binds apolipoprotein AI and a C-terminal repeat domain that binds fibro...
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ژورنال
عنوان ژورنال: The Protein Journal
سال: 2017
ISSN: 1572-3887,1573-4943
DOI: 10.1007/s10930-017-9711-4