Structure-activity studies on phosphonoacetate

Fluid-structure interaction studies on marine propeller

Composite propellers offer high damping characteristics and corrosion resistance when compared with metal propellers. But the design of a hybrid composite propeller with the same strength of metal propeller is the critical task. For this purpose, the present paper focusses on fluid-structure interaction analysis of hybrid composite propeller with Carbon/Epoxy, R-Glass/Epoxy and S2-Glass/Epoxy t...

Phosphonoformate and Phosphonoacetate

Mutants of herpes simplex virus type 1, resistant to phosphonoformate (PFA) and phosphonoacetate (PAA), have been selected in cell culture. The PFAresistant mutant (HSV-PFAr) and the PAA-resistant mutant (HSV-PAAr) were also resistant to PAA and PFA, respectively. This cross-resistance indicates that PFA and PAA interact at the same site. The HSV-PFAr had a decreased susceptibility to vidarabin...

Structure-activity Studies of Hydrazones

a-Acyl-a-cyanocarbonyl-phenylhydrazones are effective uncouplers of oxidative phosphorylation. The p/50-values of a series of 60 hydrazones with substituent variations in six positions of the molecule were determined in rat liver mitochondria. They ranged from 4.96 to 7.06. The biological data together with physico-chemical compound and substituent parameters were analysed by multiple regressio...

Structure and Activity Studies of Cyclotides STRUCTURE AND ACTIVITY STUDIES OF CYCLOTIDES

This thesis focuses on a large family of cyclic mini-proteins, namely the cyclotides, which have been discovered in a range of plants over the past decade. Around 50 cyclotide sequences have been published to date but the family is estimated to comprise hundreds or thousands of members. Most cyclotides consist of approximately 30 amino acids and have a unique and extremely stable three-dimensio...

quantitative structure activity relationship and docking studies on imidazole derivatives as p-glycoprotein inhibitors