Structure and expression of nuclear oncogenes in multi-stage thyroid tumorigenesis
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چکیده
منابع مشابه
Oncogenes and anti-oncogenes in tumorigenesis.
Recent advances have led to the identification of cellular genes which are involved in the initiation and progression of tumorigenesis. The proto-oncogenes, which normally participate in the regulation of cell proliferation and differentiation, can become oncogenes through alterations in the regulation of their expression and/or their coding sequences. Their contribution to the tumorigenic phen...
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Double transgenic mice bearing fusion genes consisting of mouse albu min enhancer/promoter-mouse c-myc complementary DNA and mouse metallothionein 1 promoter-human transforming growth factor a comple mentary DNA were generated to investigate the interaction of these genes in hepatic oncogenesis and to provide a general paradigm for character izing the interaction of nuclear oncogenes and growth...
متن کاملOncogenes in Human Thyroid Cancers
Human thyroid epithelial (follicular) cells give rise to two malignant tumors—"follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, which metastasize predominantly via lymphatics (Williams, E. D. In: W. Duncan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whethe...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1989
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1989.313