Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase

Insights into diterpene cyclization from the structure of the bifunctional abietadiene synthase from Abies grandis*

Insights into diterpene cyclization from the structure of the bifunctional abietadiene synthase from Abies grandis* Ke Zhou, Yang Gao, Julie A. Hoy, Francis M. Mann, Richard B. Honzatko and Reuben J. Peters From the Department of Biochemistry, Biophysics, & Molecular Biology, Iowa State University, Ames, IA 50011 USA Running title: Structure of abietadiene synthase Address correspondence to: Re...

A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

Terpenoids are the largest and most structurally diverse family of natural products found in nature, yet their presence in bacteria is underappreciated. The carbon skeletons of terpenoids are generated through carbocation-dependent cyclization cascades catalyzed by terpene synthases (TSs). Type I and type II TSs initiate cyclization via diphosphate ionization and protonation, respectively, and ...

Advances in polyketide synthase structure and function.

Recent progress in the understanding of polyketide synthase (PKS) continues to fuel the growth of combinatorial biosynthesis for natural product structural diversity. The structural analysis of many components of PKS, in particular for the modular type I 6-deoxyerythronilide B synthase (DEBS) involved in erythromycin biosynthesis, has provided structural imperatives for the observed biochemistr...

Identification of a Dolabellane Type Diterpene Synthase and other Root-Expressed Diterpene Synthases in Arabidopsis

Arabidopsis thaliana maintains a complex metabolism for the production of secondary or specialized metabolites. Such metabolites include volatile and semivolatile terpenes, which have been associated with direct and indirect defensive activities in flowers and leaves. In comparison, the structural diversity and function of terpenes in Arabidopsis roots has remained largely unexplored despite a ...