Structure and Variation of Three Canine Genes Involved in Serotonin Binding and Transport: The Serotonin Receptor 1A Gene (htr1A), Serotonin Receptor 2A Gene (htr2A), and Serotonin Transporter Gene (slc6A4)
نویسندگان
چکیده
منابع مشابه
Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4).
Aggressive behavior is the most frequently encountered behavioral problem in dogs. Abnormalities in brain serotonin metabolism have been described in aggressive dogs. We studied canine serotonergic genes to investigate genetic factors underlying canine aggression. Here, we describe the characterization of three genes of the canine serotonergic system: the serotonin receptor 1A and 2A gene (htr1...
متن کاملSerotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients.
BACKGROUND The serotonergic (5-HT) dysfunction has been frequently described in subjects with alcohol dependence (AD). In the present study, a potential relationship between T102C polymorphism in the 5-HT receptor subtype 2Agene (HTR2A) and alcohol dependence was examined. METHODS Genotypes were analyzed in 150 AD patients diagnosed with DSM-IV criteria and in 80 healthy controls. RESULTS T...
متن کاملIsolation and characterization of the canine serotonin receptor 1A gene (htr1A).
Although the serotonergic system and htr1A have been studied extensively, little is known about the canine serotonin receptor 1A. We are interested in this receptor in the dog because it is likely to be involved in behavioral disorders such as anxiety. Therefore, we isolated a canine bacterial artificial chromosome (BAC) clone containing htr1A, and, with the help of this clone, the complete can...
متن کاملNo association between polymorphisms in four serotonin receptor genes, serotonin transporter gene and alcohol-related suicide.
BACKGROUND Serotonin (5-HT) is an important neurotransmitter with wide-ranging functions. Its disfunction in the central nervous system seems to play an important role in many psychiatric disorders and suicidal behavior. The objective of this study was to examine the association between polymorphisms in different serotonin receptor genes (HTR): HTR1A (polymorphism -1019C>G), HTR1B (polymorphism...
متن کاملAssociation study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.
The serotonin neurotransmitter system in general, and the serotonin 1A receptor in particular, has been broadly implicated in the pathophysiology of mood and anxiety disorders, although the results of genetic association studies have been mixed. In this study, we examined the serotonin 1A receptor gene, HTR1A, for its association with shared genetic risk across a range of anxiety and depression...
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ژورنال
عنوان ژورنال: Journal of Heredity
سال: 2005
ISSN: 0022-1503,1465-7333
DOI: 10.1093/jhered/esi108