Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation
نویسندگان
چکیده
منابع مشابه
Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity
The deposition of Aβ peptide in the brain is the key event in Alzheimer disease progression. Therefore, the prevention of Aβ self assembly into disease-associated oligomers is a logical strategy for treatment. π stacking is known to provide structural stability to many amyloids; two phenylalanine residues within the Aβ 14-23 self recognition element are in such an arrangement in many solved str...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2019
ISSN: 1662-5099
DOI: 10.3389/fnmol.2019.00054