Structure-function analysis of two variants of mumps virus hemagglutinin-neuraminidase protein

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چکیده

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Structure-function analysis of two variants of mumps virus hemagglutinin-neuraminidase protein.

A point mutation from guanine (G) to adenine (A) at nucleotide position 1081 in the hemagglutinin-neuraminidase (HN) gene has been associated with neurovirulence of Urabe AM9 mumps virus vaccine. This mutation corresponds to a glutamic acid (E) to lysine (K) change at position 335 in the HN glycoprotein. We have experimentally demonstrated that two variants of Urabe AM9 strain (HN-A1081 and HN-...

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ژورنال

عنوان ژورنال: Brazilian Journal of Infectious Diseases

سال: 2009

ISSN: 1413-8670

DOI: 10.1590/s1413-86702009000100007