Structure-specific model of hemoglobin cooperativity.

Structure-specific model of hemoglobin cooperativity.

A generalization of the Szabo-Karplus statistical mechanical model for hemoglobin cooperativity is formulated. The model fits the available thermodynamic and spectroscopic data with assumptions that are consistent with structural results and empirical energy function calculations. It provides a mechanism of hemoglobin cooperativity that is a generalization of the proposals of Monod, Wyman, and ...

New Sequential Model for Human Hemoglobin: Alpha Subunit as Cooperativity Inducer

Hemoglobin is a tetrameric oxygen transport protein in animal bodies. However, there is a paucity of information regarding differences between alpha and beta subunits of hemoglobin in terms of oxygen affinity. The sequential model of Koshland, Nemthy and Filmer (KNF model) has attributed similar affinities to both alpha and beta subunits. The main purpose of the present study is to construct a ...

Some aspects of cooperativity in human hemoglobin.

new sequential model for human hemoglobin: alpha subunit as cooperativity inducer

hemoglobin is a tetrameric oxygen transport protein in animal bodies. however, there is a paucity of information regarding differences between alpha and beta subunits of hemoglobin in terms of oxygen affinity. the sequential model of koshland, nemthy and filmer (knf model) has attributed similar affinities to both alpha and beta subunits. the main purpose of the present study is to construct a ...

A general model of cooperativity and its application to DPG inhibition of hemoglobin oxygenation.

A GENERAL MODEL OF COOPERATIVITY AND ITS A P P L I C A T I O N TO DPG INHIBITION OF HEMOGLOBIN OXYGENATION Judith Herz fe ld + and H. Eugene Stanley* +Depa r tmen t of C h e m i s t r y , " D e p a r t m e n t of P h y s i c s , and +*Center for Ma te r i a l s Science and Eng inee r ing M a s s a c h u s e t t s Inst i tute of Technology, Cambr idge , M a s s a c h u s e t t s 02139 Received A...