Structure–activity relationship studies on anti-HCV activity of ring-expanded (‘fat’) nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.

A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.

Novel carbocyclic nucleosides containing a cyclobutyl ring: adenosine analogues.

(1S,1'R)-cis-1-(3'-aminomethyl-2',2'-dimethylcyclobutyl)ethanol (1) and (1S,1'R)-cis-1-[3'-(2-aminoethyl)-2',2'-dimethylcyclobutyl]ethanol (2) were used as precursors in the synthesis of cyclobutyl nucleoside analogues containing adenine and 8-azaadenine moieties, which were tested as antiviral and antitumoral agents in a variety of assay systems. Compounds 8 and 9 displayed significant activit...

Transmittance of MIM Waveguides Containing Semi-Circular Ring Shaped and Rectangular Ring Shaped Grooves

In this paper the transmittance of metal-insulator-metal (MIM) waveguides containing semi-circular ring shaped and rectangular ring shaped grooves are investigated. By varying groove parameters their effects on the transmittance of the MIM waveguides are investigated. The results show that the transmittance spectra of the waveguides have maximum and minimum points, and by using appropriate para...

Analogues of the Ring of Rational Integers

AN APPROACH TO THE A RING OF VITAMIN D ANALOGUES VIA SEQUENTIAL CARBOMETALATION/ ANION CAPTURE

An intramolecular palladium catalysed carbometalation followed by anion capture achieves construction of a model comprised of the A ring of Vitamin D oxygen analogues.