Studies on the Inhibition of Actinomycin Biosynthesis by d-Valine
نویسندگان
چکیده
منابع مشابه
On the Recovery of Transcription after Inhibition by Actinomycin D
After pulse exposure to concentrations of actinomycin D (AMD) sufficient to abolish transcription, Vero cells recover RNA synthesis much more rapidly than most other cell types. This is only in part attributable to the remarkable capacity of Vero very promptly to excrete bound AMD, elimination of which, although necessary, is not a sufficient condition for resurgence of RNA synthesis. After eli...
متن کاملInhibition of Mycoplasma pneumoniae by actinomycin D.
Growth of Mycoplasma pneumoniae was completely prevented by 0.06 mug of actinomycin D/ml, and 0.00375 mug/ml caused 90% inhibition. It thus appears that M. pneumoniae is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 mug/ml) of the antibiotic primarily inhibited ribonucleic acid synthesis and high concentrations (20 mug/ml) inhibited both ribonucleic and d...
متن کاملInhibition by actinomycin D of oxidation-dependent biosynthesis in Sarcoma 37 ascites cells.
When Sarcoma 37 ascites cells were incubated in the presence of actinomycin D, protein synthesis was inhibited. The inhibitory effect could be prevented or relieved by glucose or by a variety of glycolyzable substrates. The inhibitory effect was independent of the concentration of the labeled amino acid precursor. Under conditions inhibitory to protein synthesis, no significant inhibition of re...
متن کاملThe inhibition of a biological clock by actinomycin D.
I Cahn, R. I)., N. 0. Kaplan, L. Levine, and S. White, Fed. Proc., 21, 407 (1962). 6 Brand, L., J. Everse, and N. 0. Kaplan, Biochemistry, 1, 423 (1962). 7 Cahn, R. D., Ph.D. dissertation, Brandeis University (1962). 8 Wieme, R. J., and J. E. Herpol, Nature, 194, 287 (1962). 9 Fine, I. H., N. 0. Kaplan, and D. Kuftinec, Biochemistry, in press. 10 Fine, I. H., N. 0. Kaplan, and S. White, Fed. Pr...
متن کاملExperimental studies with actinomycin D.
Actinomycin D has been tested on mouse tu mors, with varying degrees of success, as an anti-neoplastic agent. Dramatic inhibition of some ascites (mouse) tumors has been reported by Sugiura (14) and Gregory et al. (6). Reilly (11) and Sugiura (14) are in agreement that actino-mycin D has slight antineoplastic activity against S-180, and Farber (3) demonstrated antitumor activity against the mal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1967
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)96254-x