Study on sustained-release metformin hydrochloride from matrix tablet: Influence of hydrophilic polymers and in vitro evaluation
نویسندگان
چکیده
منابع مشابه
Formulation of Sustained Release Metformin Hydrochloride Matrix Tablets: Influence of Hydrophilic Polymers on the Release Rate And In Vitro Evaluation
Metformin HCL, the only available biguanide, remains the first line drug therapy for patients with Type 2 diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. It has relatively short plasma half life, low absolute bioavailability. The overall objective of the present work was to develop an oral sustained release metformin tablet prepared by direct compr...
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The objective of present work is to develop and characterize an oral sustained release matrix tablet of complexedNicardipine Hydrochloride by employing hydrophilic and hydrophilic polymers. Due to poor water solubility of the drug its bioavailability is dissolution rate limited. The purpose of the study was to increase the solubility of Nicardipine by cyclodextrin inclusion complex technique. C...
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Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointest...
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The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique. In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two g...
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Frequent dosing of the potent anti-androgen, flutamide, is necessary to reach a therapeutic level for the treatment of prostatic carcinoma. Sustained delivery of the drug could reduce the adverse effects such as gastrointestinal disorders and improve patient compliance. In the present study sustained-release matrix tablets of flutamide were prepared by direct compression method using different ...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Investigation
سال: 2011
ISSN: 2230-973X
DOI: 10.4103/2230-973x.85966