Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells

Exosomes are membranous lipid vesicles fused with intracellular multicellular bodies and then released into the extracellular environment. They contain various bioactive substances, including proteins, mRNA, miRNAs, lncRNAs, circRNAs, lipids, transcription factors, cytokine receptors. Under certain conditions, bone marrow mesenchymal stem cells (BMSCs) can differentiate osteoblasts, chondrocytes, adipocytes, biological functions. This study provides a theoretical basis for application of exosomes derived from (BMSC-Exos) in osteology, exploring different sources to improve microenvironment resist metastasis. We also provided new ideas prevention rehabilitation human diseases by exosomes.