Subtherapeutic Antiretroviral Plasma Concentrations in Routine Clinical Outpatient HIV Care
نویسندگان
چکیده
منابع مشابه
Protease inhibitor plasma concentrations in HIV antiretroviral therapy.
Since the introduction of the HIV protease inhibitors in 1995, considerable progress has been made in the treatment of HIV-infected patients. However, treatment has not been without problems. Studies have demonstrated associations between protease inhibitor concentrations and efficacy and in some cases toxicity. As considerable inter-individual and intra-individual variations of protease inhibi...
متن کاملPlasma and Intracellular Antiretroviral Concentrations in HIV-Infected Patients under Short Cycles of Antiretroviral Therapy
Study of plasma and intracellular concentrations of atazanavir, lopinavir, nevirapine, and efavirenz was conducted on 48 patients under short cycles of antiretroviral therapy. Intracellular concentrations (IC) were still measurable for all drugs after 85 h or 110 h drug intake despite the absence of drug in plasma for atazanavir and lopinavir. A linear relationship between plasma and intracellu...
متن کاملRisk factors for virological failure and subtherapeutic antiretroviral drug concentrations in HIV-positive adults treated in rural northwestern Uganda
BACKGROUND Little is known about immunovirological treatment outcomes and adherence in HIV/AIDS patients on antiretroviral therapy (ART) treated using a simplified management approach in rural areas of developing countries, or about the main factors influencing those outcomes in clinical practice. METHODS Cross-sectional immunovirological, pharmacological, and adherence outcomes were evaluate...
متن کامل[The interruption of outpatient clinical care of HIV-infected patients].
OBJECTIVE To determine factors associated with the interruption of outpatient care of HIV-positive patients. METHODS Non-concurrent prospective study carried out in a public AIDS referral center in Belo Horizonte, Brazil. Medical records were reviewed in order to assess factors associated with the interruption of clinical care of HIV patients admitted between 1993 and 1995. Patients should ha...
متن کاملFood intake and darunavir plasma concentrations in people living with HIV in an outpatient setting
AIMS Patients receiving darunavir are advised to take it concomitantly with food. The objectives of the present cross-sectional study were to evaluate the actual concomitant food intake of patients visiting an HIV outpatient clinic. METHODS Sixty participants treated with darunavir/ritonavir once daily were subjected to a food recall questionnaire concerning their last concomitant food intake...
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ژورنال
عنوان ژورنال: Therapeutic Drug Monitoring
سال: 2003
ISSN: 0163-4356
DOI: 10.1097/00007691-200306000-00018