Subunit-dependent cadmium and nickel inhibition of acid-sensing ion channels
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چکیده
منابع مشابه
Subunit and frequency-dependent inhibition of Acid Sensing Ion Channels by local anesthetic tetracaine
BACKGROUND Extracellular acidosis is a prominent feature of multiple pathological conditions, correlating with pain sensation. Acid-sensing ion channels (ASICs), a family of proton-gated cation channels, are distributed throughout the central and peripheral nervous systems. Activation of ASICs, particularly ASIC3 and ASIC1a channels, by acidic pH and the resultant depolarization of nociceptive ...
متن کاملSubunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.
Acid-sensing ion channels (ASICs), a novel class of ligand-gated cation channels activated by protons, are highly expressed in peripheral sensory and central neurons. Activation of ASICs may play an important role in physiological processes such as nociception, mechanosensation, and learning-memory, and in the pathology of neurological conditions such as brain ischemia. Modulation of the activi...
متن کاملSubunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1
There are five mammalian stomatin-domain genes, all of which encode peripheral membrane proteins that can modulate ion channel function. Here we examined the ability of stomatin-like protein 1 (STOML1) to modulate the proton-sensitive members of the acid-sensing ion channel (ASIC) family. STOML1 profoundly inhibits ASIC1a, but has no effect on the splice variant ASIC1b. The inactivation time co...
متن کاملAcid-Sensing Ion Channels
Acetylcholine is a neurotransmitter synthesized from choline and acetyl coenzyme A. It is localized in large reticular formation neurons, and is the chemical mediator in the synapse of a motor endplate. The electrical signal of the motor nerve terminal causes release of many packets of acetylcholine. The packets are released into the synaptic cleft, where receptors in the postjunctional membran...
متن کاملAcid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition.
Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl(-)-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We previously found that anions modulate ASIC1a gating via these sites. Here we investigated the effect of anion substitution on native ASICs in rat sensory neurons and hetero...
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ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2006
ISSN: 1932-8451,1932-846X
DOI: 10.1002/dneu.20338