Successful Combined Sequential Treatment with Two Bypassing Agents in a Hemophilia A Patient with High-Responding Inhibitor Induced Refractory Bleeding
نویسندگان
چکیده
منابع مشابه
Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors
Background: The development of inhibitors is a complication factor replacement therapy in hereditary factor VIII deficiency. Several management options are available for the treatment of inhibitor. Rituximab, a monoclonal antibody against CD20, reduces inhibitor level in rare bleeding disorders. The aim of this study was to evaluate the effectiveness of rituximab in lowering or eliminating the ...
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Angioedema secondary to C1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. A genetic defect of C1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported.In lupus patients, angioedema may be the result of an ac...
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The development of inhibitors against administered clotting factors may render replacement therapy ineffective for some hemophilia patients. Such patients are therefore at the highest risk of developing arthropathy. Elective orthopedic surgery (EOS) in hemophilic patients having such inhibitors remains a rare, expensive, and difficult surgery, whose management represents a significant challenge...
متن کاملcomparison of bypassing agents in bleeding reduction in treatment of bleeding episodes in patients with haemophilia and inhibitors
conclusions although differences between the two products were very close to each other, they reported similar effects on joint bleeds. further clinical studies should be performed by incorporating a standardized measurement in comparative efficacy of apcc and rfviia. results the mean of bleeding reduction in apcc and rfviia were 71.2% with ci 95% (lower limit 86.8% and upper limit 82%) and 72....
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ژورنال
عنوان ژورنال: Clinical & Experimental Thrombosis and Hemostasis
سال: 2014
ISSN: 2288-8209,2288-8217
DOI: 10.14345/ceth.14009