Supercharging enables organized assembly of synthetic biomolecules

Photochemistry of highly organized biomolecules: Sequence-select

described. One example includes a specific photocleavage of DNA duplex at 5' side of 5'-GG-3' sequence by a "photo-Fenton reagent", whereas the other is the sequenceselective photoreaction of S-AB'Usite of DNA duplex which results in formation of a 2-deoxyribonolactone residue with release of free adenine via selective hydrogen abstraction from C2' of deoxyribose residue. Two types of highly se...

Peptide and protein building blocks for synthetic biology: from programming biomolecules to self-organized biomolecular systems.

There are several approaches to creating synthetic-biological systems. Here, we describe a molecular-design approach. First, we lay out a possible synthetic-biology space, which we define with a plot of complexity of components versus divergence from nature. In this scheme, there are basic units, which range from natural amino acids to totally synthetic small molecules. These are linked togethe...

Simulating biomolecules in synthetic nanopores

DNA-guided Assembly of Organized Nano-Architectures

Incorporation of DNA into nano-object design provides a unique opportunity to establish highly selective and reversible interactions between the components of nanosystems. Assembly approaches based on the nanoobject’s addressability promise powerful routes for creation of rationally designed nano-systems for the development of novel magnetic, photonic and plasmonic metamaterials. DNA provides a...

Structural investigation of multivalent carbohydrate-protein interactions using synthetic biomolecules.

Understanding multivalent carbohydrate-protein interactions at the molecular level requires access to structural details of these important biological recognition processes. Recent developments toward this goal comprise the use of conformationally defined molecular rulers in combination with binding assays, crystallographic investigation of complexes of multivalent ligands and their target prot...