Surface Functionalization of Exosomes Using Click Chemistry
نویسندگان
چکیده
منابع مشابه
Surface Functionalization of Exosomes Using Click Chemistry
A method for conjugation of ligands to the surface of exosomes was developed using click chemistry. Copper-catalyzed azide alkyne cycloaddition (click chemistry) is ideal for biocojugation of small molecules and macromolecules to the surface of exosomes, due to fast reaction times, high specificity, and compatibility in aqueous buffers. Exosomes cross-linked with alkyne groups using carbodiimid...
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We describe a new method to covalently link a wide variety of molecules to the surface of colloidal polymer microspheres using the Cu(I)-catalyzed azide-alkyne reaction, most commonly known under the class of reactions identified by the term click chemistry. The method is generic and readily applied to a spectrum of colloidal particle systems allowing surfaces to be tailored with virtually any ...
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Proof-of-principle studies are described which show unequivocally that Huisgen click coupling can be performed successfully at the surface of polymer nano/submicron-size particles dispersed in aqueous media, thereby defining a generic strategy for attachment of a wide variety of functional molecules and providing a powerful, versatile route for the synthesis of surface functional particles.
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A solution method for preparing surface functionalized colloidal silicon quantum dots (SiQDs) is presented. SiQDs prepared by this method are reasonably monodispersed and can be further functionalized via thiol-ene click reactions to introduce specific functionalities (i.e. -NH(2), -COOH, -SO(3)(-), alkane, alkene).
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2014
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc500291r