Surface loops of extracellular phospholipase A1 determine both substrate specificity and preference for lysophospholipids
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چکیده
منابع مشابه
Acyl and phosphoryl migration in lysophospholipids: importance in phospholipid synthesis and phospholipase specificity.
Three isomeric lysophosphatidylcholines (1-palmitoyl-sn-glycero-3-phosphorylcholine, 2-palmitoyl-snglycero-3-phosphorylcholirte, and 3-palmitoyl-sn-glycero-2phosphorylcholine) have been prepared by the action of phospholipase A2 or lipase on I ,2-dipalmitoyl-sn-glycero-3phosphorylcholine or phospholipase A2 on 1 ,3-dipalmitoylsn-glycero-2-phosphorylcholine. The structures of the lyso compounds ...
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In the present study, we investigated the ability of an immobilized phospholipase A1 (PLA1) in degumming of soybean oil. The enzyme was immobilized by simple adsorption on bentonite without any further modification. The free and immobilized PLA1 were characterized by Fourier Transform InfraRed (FT-IR) spectroscopy and X-Ray Diffraction (XRD). The immobilizat...
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BACKGROUND Lung cancer and glioblastoma multiforme are highly angiogenic and, despite advances in treatment, remain resistant to therapy. Cytosolic phospholipase A2 (cPLA(2)) activation contributes to treatment resistance through transduction of prosurvival signals. We investigated cPLA(2) as a novel molecular target for antiangiogenesis therapy. METHODS Glioblastoma (GL261) and Lewis lung ca...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2012
ISSN: 0022-2275
DOI: 10.1194/jlr.m022400