Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε
نویسندگان
چکیده
منابع مشابه
Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled
Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this pathway by transducing the signal from the Wnt receptor complex to the -catenin destruction complex. Dvl also plays a pivotal role in the planar cell polarity pathway that involves the c-Jun N-terminal kinase (JNK...
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The Wnt/ -catenin signaling pathway is important in both development and cancer. Casein kinase I (CKI ) is a positive regulator of the canonical Wnt pathway. CKI itself can be regulated in vitro by inhibitory autophosphorylation, and recent data suggest that in vivo kinase activity can be regulated by extracellular stimuli. We show here that the phosphorylation state and kinase activity of CKI ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m103555200