Synergistic Effects of Antimicrobial Peptides and Antibiotics against Clostridium difficile
نویسندگان
چکیده
منابع مشابه
Synergistic effects of antimicrobial peptides and antibiotics against Clostridium difficile.
Accelerating rates of health care-associated infections caused by Clostridium difficile, with increasing recurrence and rising antibiotic resistance rates, have become a serious problem in recent years. This study was conducted to explore whether a combination of antibiotics with human antimicrobial peptides may lead to an increase in antibacterial activity. The in vitro activities of the antim...
متن کاملClostridium difficile--beyond antibiotics.
In this decade, the prevention and control of Clostridium difficile infection in health care settings has become a global public health challenge. Infection rates have increased dramatically, and several large outbreaks associated with toxinotype III BI/NAP1/027 strains have been described.1 One of the major incongruities in the management of C. difficile infection is that antibiotics are the m...
متن کاملAntimicrobial peptides from wild bee venom and antibiotics: Synergistic effect against Pseudomonas aeruginosa
Antimicrobial peptides (AMPs) from the venom of Hymenoptera insect are known for their broad spectrum of antimicrobial activity including Gram-negative and Gram-positive bacteria as well as fungi [1,2]. Although the exact mechanism of their action is still not exactly known, it is accepted that these positively charged peptides target the anionic bacterial cell envelope and then disrupt its str...
متن کاملAntimicrobial activities of synthetic bismuth compounds against Clostridium difficile.
Clostridium difficile is a major nosocomial pathogen responsible for pseudomembranous colitis and many cases of antibiotic-associated diarrhea. Because of potential relapse of disease with current antimicrobial therapy protocols, there is a need for additional and/or alternative antimicrobial agents for the treatment of disease caused by C. difficile. We have synthesized a systematic series of ...
متن کاملAntimicrobial activity of natural products against Clostridium difficile in vitro.
AIMS To investigate the antimicrobial activity of various natural products against Clostridium difficile in vitro. METHODS AND RESULTS The antibacterial activity of 20 natural products was determined by the agar well diffusion and broth microdilution assays against four C. difficile strains, three comparator organisms and four gastrointestinal commensal organisms. Of the raw natural products,...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02542-14