Synthesis and utilization of optically active α-aminophosphonate derivatives by Kabachnik-Fields reaction
نویسندگان
چکیده
منابع مشابه
Facile synthesis of optically active imidazole derivatives.
Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding alpha-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imid...
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The Kabachnik-Fields (phospha-Mannich) reaction involving the condensation of primary or secondary amines, oxo compounds (aldehydes and ketones) and >P(O)H species, especially dialkyl phosphites, represents a good choice for the synthesis of α-aminophosphonates that are of significant importance due to their biological activity. In general, these three-component reactions may take place via a...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2017
ISSN: 0040-4020
DOI: 10.1016/j.tet.2017.07.060