Synthesis of Macrocyclic Tetrazoles for Rapid Photoinduced Bioorthogonal 1,3-Dipolar Cycloaddition Reactions
نویسندگان
چکیده
منابع مشابه
Synthesis and 1,3-Dipolar Cycloaddition Reactions of Chiral Maleimides
New routes to the synthesis of various novel chiral maleimides are described. The oxabicyclic anhydride 2 readily available exo-Diels-Alder adduct of furan and maleic anhydride was used as a vehicle, which in turn reacted with hydrochlorides of amino acids 3a-f in the presence of Et3N with release of furan to give the requisite novel chiral imides 4a-f in good to moderate yields. The stereosele...
متن کاملRhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions
The rhodium(II)-catalyzed formation of 1,3-dipoles has played a major role in facilitating the use of the dipolar cycloaddition reaction in modern organic synthesis. This is apparent from the increasing number of applications of this chemistry for the construction of heterocyclic and natural product ring systems. This chapter initially focuses on those aspects of rhodium(II) catalysis that cont...
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We report the first use of a photoinduced 1,3-dipolar cycloaddition reaction in "stapling" peptide sidechains to reinforce a model peptide helical structure with moderate to excellent yields; the resulting pyrazoline "staplers" exhibit unique fluorescence useful in a cell permeability study.
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The first transannular [4 + 2] cycloaddition reactions of macrocyclic dicobalt hexacarbonyl-dienyne complexes were demonstrated. Complexes were conveniently prepared through palladium(II)-catalyzed intramolecular oxidative cyclization of bis(vinylboronate esters) followed by complexation with dicobalt octacarbonyl. Transannular [4 + 2] cycloaddition reactions of the complexes occurred at lower ...
متن کامل1,3-dipolar cycloaddition reactions of N-methyl-substituted tricyclic imides.
The [3+2] cycloadditions of N-methyl derivatives of unsaturated imides with various nitrile oxides to yield new bridged isoxazoline derivatives with potential biological activity is described.
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2010
ISSN: 0947-6539
DOI: 10.1002/chem.201002360