Synthesis of Thiamine Alkyl Disulfides
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چکیده
منابع مشابه
Inhibition of thiamine transport in Saccharomyces cerevisiae by thiamine disulfides.
Both thiamine disulfide and O-benzoyl thiamine disulfide, which are thiolfrom derivatives of thiamine, strongly inhibited thiamine transport in Saccharomyces cerevisiae. The inhibition appeared to be due to a high affinity of the analogs for yeast cell membranes, in which thiamine transport component(s) may be integrated.
متن کاملEfficient synthesis of unsymmetrical disulfides
A novel way of synthesizing unsymmetrical disulfides from thiols with DDQ is presented here. This procedure ran in a straightforward manner to give high product yields. Unsymmetrical disulfides were directly synthesized from the corresponding mixture of thiols in equimolar amounts under mild conditions. 2011 Elsevier Ltd. All rights reserved.
متن کاملSelf-Assembled Monolayers of Symmetrical and Mixed Alkyl Fluoroalkyl Disulfides on Gold. 1. Synthesis of Disulfides and Investigation of Monolayer Properties
The synthesis of a variety of symmetrical bis(alkyl) and bis(fluoroalkyl) disulfides as well asmixed alkyl fluoroalkyl disulfides containing ester or amide groups is described. Self-assembled monolayers of these compounds on gold formed by spontaneous adsorption from solution are studied by contact angle measurementsandpolarizedgrazing incidenceFourier transforminfraredspectroscopy (FTIR). The ...
متن کاملThe enzymatic synthesis of thiamine monophosphate.
The catalysis, by the enzyme thiaminase, of reversible baseexchange reactions between thiamine and aromatic tertiary amines was first reported by Fujita et al. (1). Related findings with mammalian diphosphopyridine nucleotidases (2) and with methionine activation (3) drew attention to the energy-rich nature of “onium” (4-6) compounds and suggested that the alkylation of thiazole must involve ac...
متن کاملNovel strategies for the synthesis of unsymmetrical glycosyl disulfides.
Novel strategies for the efficient synthesis of unsymmetrical glycosyl disulfides are reported. Glycosyl disulfides are increasingly important as glycomimetics and molecular probes in glycobiology. Sialosyl disulfides are synthesised directly from the chlorosialoside Neu5Ac2Cl, proceeding via a thiol-disulfide exchange reaction between the sialosyl thiolate and symmetrical disulfides. This meth...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1954
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.74.9_963