Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B
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چکیده
منابع مشابه
Synthetic studies on pseudo-dimeric Lycopodium alkaloids: total synthesis of complanadine B.
Complanadines A and B (1 and 2, Scheme 1) are dimeric Lycopodium alkaloids from the lycodine family that possess significant activity for stimulating nerve growth factor (NGF) production in human glial cells. 2] As such, 1 and 2 are of interest as potential small-molecule leads for the treatment of neurodegenerative diseases, such as Alzheimer s disease, as well as adjuvants for the regeneratio...
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The collective total synthesis of Lycopodium alkaloids (+)-fawcettimine (1), (+)-fawcettidine (2), (+)-alopecuridine (4), (-)-lycojapodine A (6), and (-)-8-deoxyserratinine (7) has been accomplished from a common precursor (15) based on a highly concise route inspired by the proposed biosynthesis of the fawcettimine- and serratinine-type alkaloids. An intramolecular C-alkylation enabled efficie...
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Paniculatine 1, magnellanine 2. and magnellaninone 3 are three structurally similar tetracyclic alkaloids isolated and characterized by Castillo in 1976.3 Despite their unusual and interesting structures, there has been a paucity of effort directed toward the synthesis of this class of alkaloids.3 We report hem our studies on the synthesis and characterization of two tricyclic intermediates whi...
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[Chemical reaction: See text] The synthesis of stevastelin B3 (2) and B (5) are described. In a first approach, epoxy cyclodepsipeptide 8 was considered as a promising candidate for the synthesis of the [15]-membered ring members of the stevastelins; however, the oxirane ring opening, required for the completion of the natural stevastelin synthesis, failed. Thus, we synthesized stevastelin B (5...
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2013
ISSN: 0044-8249
DOI: 10.1002/ange.201208571