Systematic development of a mobile preconception lifestyle programme for couples undergoing IVF: the PreLiFe-programme

Abstract STUDY QUESTION Can we develop a preconception lifestyle programme for couples undergoing IVF that is in line with their needs. SUMMARY ANSWER A mobile was systematically developed based on expert opinion, literature and needs of IVF-patients. WHAT IS KNOWN ALREADY healthy prior to conception not only beneficial the general health couples, but evidence its importance reproductive children also emerging. So far, vast majority fertility clinics do offer IVF. Therefore, present study aimed IVF-couples. DESIGN, SIZE, DURATION The development PreLiFe-programme guided by steps Medical Research Council (MRC) framework developing complex interventions, systematic approach theory- evidence-based promotion interventions. PARTICIPANTS/MATERIALS, SETTINGS, METHODS First, base programmes IVF-couples reviewed. Second, several iterations between an panel, literature, quantitative qualitative data from IVF-patients identified content, format, behaviour change techniques theory programme. Third, produced expected process outcomes randomized controlled trial assessing it were modelled. Finally, user tests among experts patients pilot conducted. MAIN RESULTS AND ROLE OF CHANCE finally application be used autonomously both partners during first year IVF, combination motivational interviewing over telephone every three months (i.e. blended care). provides advice skills training physical activity, diet mindfulness stress reduction part tailored monitoring tracking patients. Based panel considers plausible all components contribute IVF-success rates. likely acceptable as meets need treatment information. LIMITATIONS, REASON FOR CAUTION had 3-month duration. feasibility other infertile populations and/or upon longer use yet examined. Whether effectively improves rates currently being examined randomizing heterosexual starting or attention-control group 12 months. WIDER IMPLICATIONS THE FINDINGS If chance IVF-success, will powerful tool provide guidance implementing clinics. FUNDING/COMPETING INTEREST(S) Funded Foundation Flanders (FWO-TBM (Applied Biomedical Primary Social finality); reference: T005417N). authors have no conflict interest report. TRIAL REGISTRATION NUMBER NCT03790449.