Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
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چکیده
منابع مشابه
Checkpoint recovery after DNA damage: a rolling stop for CDKs.
The cyclin-dependent kinases (CDKs) must be inhibited when DNA damage occurs to prevent cell-cycle progression and to allow for repair. A paper in the June issue of EMBO reports from Rene Medema’s group now suggests that some CDK activity must actually be retained during arrest for efficient checkpoint recovery to occur (Alvarez-Fernández et al, 2010). Cells have evolved several mechanisms to e...
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15 صفحه اولPP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint
Phosphorylation of histone H2AX on Ser 139 (gammaH2AX) is one of the earliest events in the response to DNA double-strand breaks; however, the subsequent removal of gammaH2AX from chromatin is less understood, despite being a process tightly coordinated with DNA repair. Previous studies in yeast have identified the Pph3 phosphatase (the PP4C orthologue) as important for the dephosphorylation of...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-05639-x