T Helper Lymphocytes Rescue CTL from Activation-Induced Cell Death

Activation-Induced Cell Death T Helper Lymphocytes Rescue CTL from

CD5-Deficient Mice Enhances the Antitumor CTL Response in from Activation-Induced Cell Death Rescue of Tumor-Infiltrating Lymphocytes

Functional avidity-driven activation-induced cell death shapes CTL immunodominance.

Immunodominance is a complex phenomenon that relies on a mere numerical concept, while being potentially influenced at every step of the immune response. We investigated the mechanisms leading to the establishment of CTL immunodominance in a retroviral model and found that the previously defined subdominant Env-specific CD8(+) T cells are endowed with an unexpectedly higher functional avidity t...

Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying t...

Activation-Induced T Cell Death Exacerbates