TAN-999 and TAN-1030A, new indolocarbazole alkaloids with macrophage-activating properties.
نویسندگان
چکیده
منابع مشابه
TAN-999 and TAN-1030A, new indolocarbazole alkaloids with macrophage-activating properties.
Two new indolocarbazole alkaloids, TAN-999 and TAN-1030A, were isolated from culture broths of Nocardiopsis dassonvillei C-71425 and Streptomyces sp. C-71799, respectively. Their structures were elucidated on the basis of their reactions, spectroscopic analyses and in particular, comparison of spectral data with that of staurosporine. These metabolites induced spreading of a murine macrophage c...
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The nanomolar kinase inhibitory activity of staurosporine (1) and K252a (5) has prompted a continuing effort to isolate and/or synthesize novel pyranosylated and furanosylated indolocarbazoles.l,2,3. 4 Recently, we reported the enantioselective synthesis of (+)-K252a via an approach involving the late-stage coupling of aglycon 8 and furanose 9 (Scheme 1). Although this approach proved efficient...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1989
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.42.1619