Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest

Targeted temperature management after cardiac arrest.

• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please...

Targeted Temperature Management after Cardiac Arrest

Targeted temperature management at 33°C versus 36°C after cardiac arrest.

BACKGROUND Unconscious survivors of out-of-hospital cardiac arrest have a high risk of death or poor neurologic function. Therapeutic hypothermia is recommended by international guidelines, but the supporting evidence is limited, and the target temperature associated with the best outcome is unknown. Our objective was to compare two target temperatures, both intended to prevent fever. METHODS...

Prognostication of outcome after cardiac arrest and targeted temperature management

The vast majority of cardiac arrest (CA) survivors remain comatose at hospital arrival. Around one-half of these patients suffer from severe hypoxic encephalopathy leading to death or unresponsive wakefulness. Early outcome prognostication may reduce futile intensive care and suffering for next of kin. Several early prognostic markers have shown high positive predictive value for poor outcome i...

Targeted Temperature Management (TTM) for Comatose Survivors of Cardiac Arrest

Animal data has long supported the concept of managing temperature by inducing hypothermia following cardiac arrest to improve neurological outcome. In 2002 two landmark trials were published in the New England Journal of Medicine (NEJM); A European multicentre trial with a total of 136 patients compared therapeutic hypothermia of 32-34 for 24 hours to normothermia and demonstrated 55% vs 39% f...