Targeting Alzheimer's Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Dise ase Pathologies

Targeting Alzheimer’s Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Disease Pathologies

BACKGROUND Alzheimer's disease (AD) could be regarded as a brain form of diabetes since insulin resistance and deficiency develop early and progress with severity of neurodegeneration. Preserving insulin's actions in the brain restores function and reduces neurodegeneration. T3D-959 is a dual nuclear receptor agonist currently in a Phase 2a trial in mild-to-moderate AD patients (ClinicalTrials....

A NEONATAL PRESENTATION OFCAROLI\'S DISE ASE WITH SEVERE ABDOMINAL DISTENTION AS A PRESENTING SYMPTOM

In this article , the authors introduce a case of Caroli's Disease (CD) according to the results of ultrasonography (U.S), abdominal computed tomography (CT scan) and hepatic biopsy that has been manifested in the neonatal period. In the routine examination of the neonate, abdominal protrusion was noticed. Then milk intoterance, inability of meconium passage and vomiting developed, during w...

Targeting Protein Stability with a Small Molecule

Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banaszynski et al. (2006) now describe a strategy to regulate the stability of a target protein, in which specificity is provided by a genetically encoded tag and temporal control is imparted by a small molecule.

C Stem - cell therapy in retinal dise ase

Current Opinion in Ophthalmology 2009, 20:175–181 Purpose of review Stem-cell research is being investigated for the treatment of retina diseases. Cell replacement strategies have the potential to improve vision in patients who were previously considered to be untreatable. This review summarizes progress within the field and obstacles which must be overcome to make stem-cell therapy a viable tr...

IL - 6 Receptor A Novel Small - Molecule Inhibitor Targeting