Targeting gamma secretase: has progress moved up a Notch?

Gamma secretase inhibitors of Notch signaling

The numerous processes involved in the etiology of breast cancer such as cell survival, metabolism, proliferation, differentiation, and angiogenesis are currently being elucidated. However, underlying mechanisms that drive breast cancer progression and drug resistance are still poorly understood. As we discuss here in detail, the Notch signaling pathway is an important regulatory component of n...

'Handling a complaint after a patient has moved'.

The role of Notch and gamma-secretase inhibition in an ovarian cancer model.

BACKGROUND The Notch pathway is dysregulated in ovarian cancer. We sought to examine the role of Notch and gamma-secretase (GS) inhibition in ovarian cancer. MATERIALS AND METHODS Established ovarian cancer cell lines were used. Quantitative polymerase chain reaction (qPCR) was used to determine the relative expression of Notch receptor and ligands. Effects of GS inhibition on proliferation, ...

Gamma secretase inhibitor blocks Notch activation and prevented osteosarcoma cells proliferation in vitro and in vivo

Has the world moved forward? A robust multidimensional evaluation

a r t i c l e i n f o This paper presents a multidimensional normative framework to evaluate whether the world moved forward between 1980 and 2008. We focus on the robustness of the results when attributing different weights to the different dimensions. Population-weighted international welfare has not worsened over this period. However, the trend in the underlying inequality is ambiguous, once...