Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways

targeting gastric cancer stem cells through developmental pathways: hypothesis

cancer stem cells (cscs) have been defined as a unique subpopulation in tumors, endowed with the capacity to initiate tumor progression, maintain self-renewal as well as metastatic potential. recently, more evidence strongly indicates the existence of cscs in solid tumors of wide variety of organs such as breast, brain and stomach. recent studies suggest that a special subpopulation of gastric ...

Alternative pathways of T lymphocyte activation

Data presented in this paper suggest that there may be two alternative pathways which T lymphocytes can use in generating a cytotoxic response to alloantigens in vitro. First, there is the pathway taken when stimulator and responder cells differ by an entire H-2 complex where Ly1+2- helper T lymphocytes respond to I region encoded lymphocyte defined differences and provide help to the Ly1-2+ cy...

Molecular Pathways Targeting Hypoxic Cells through the DNA Damage Response

Exposure to hypoxia-induced replication arrest initiates a DNA damage response that includes both ATRand ATM-mediated signaling. DNA fiber analysis was used to show that these conditions lead to a replication arrest during both the initiation and elongation phases, and that this correlated with decreased levels of nucleotides. The DNA damage response induced by hypoxia is distinct from the clas...

The Role of miRNA Dysregulation in Thyroid Cancer Development by Targeting the Main Signaling Pathways

Thyroid cancer is one of the most common malignancies of endocrine glands, causing carcinomas, such as papillary, follicular, medullary, and anaplastic thyroid carcinomas. Due to the significance of thyroid carcinomas, identification of the main signaling pathways and  the affecting mutations has been considered by researchers. Further studies on the dysregulation of oncogenes in signaling path...

Proliferative Signaling Pathways Lymphocyte Activation by Targeting Key Nematode-Secreted Product Disrupts B A Phosphorylcholine-Containing Filarial