Targeting Mitochondrial Function in Heart Failure
نویسندگان
چکیده
منابع مشابه
Targeting Mitochondrial Oxidative Stress in Heart Failure
Oxidative stress contributes to various cardiovascular diseases and aging and was causally linked to the progression of heart failure (1,2). Among the most relevant sources for reactive oxygen species (ROS) are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and mitochondria (1,3–7). The ROS impair excitation-contraction coupling, cause arrhythmias, and contribute to cardiac remode...
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MicroRNAs play pivotal roles in cardiac disease, and their therapeutic modulation raises exciting and unique opportunities, as well as challenges in the path toward clinical development and implementation. In this review, we provide a detailed overview of recent studies highlighting the important role of microRNAs in heart failure (HF) and the potential use of microRNA-based technology for diag...
متن کاملMitochondrial dysfunction in heart failure.
angina was reached. Angina, unfortunately, is a subjective measure. Irrespective of how “objective” the investigators were in determining the success or failure of antianginal therapy, the use of a subjective end point may have inadvertently introduced bias into the trial. It is difficult to draw proper conclusions from such a trial when large crossover rates are allowed. With respect to the Eu...
متن کاملAldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.
AIMS We previously demonstrated that pharmacological activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) protects the heart against acute ischaemia/reperfusion injury. Here, we determined the benefits of chronic activation of ALDH2 on the progression of heart failure (HF) using a post-myocardial infarction model. METHODS AND RESULTS We showed that a 6-week treatment of myocardial inf...
متن کاملTargeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure
Improved treatments for heart failure patients will require the development of novel therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca(2+) homeostasis is recognized as a major contributor to the heart failure phenotype, as it plays a key role in systolic and diastolic dysfunction, arrhythmogenesis, and hypertrophy and apoptosis signaling. In this review, we...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2019
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2019.03.003