Targeting nuclear import and export in hematological malignancies
نویسندگان
چکیده
منابع مشابه
Selective inhibitors of nuclear export (SINE) in hematological malignancies
Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is responsible for the nucleo-cytoplasmic transport of more than 200 proteins, including most of the tumor suppressor proteins (TSP). CRM1 is overexpressed in pancreatic cancer, osteosarcoma, glioma, cervical and hematological malignancies....
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ژورنال
عنوان ژورنال: Leukemia
سال: 2020
ISSN: 0887-6924,1476-5551
DOI: 10.1038/s41375-020-0958-y