Targeting the Cyclins
نویسندگان
چکیده
منابع مشابه
Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms.
D-type cyclins (cyclins D1, D2, and D3) promote G1-S progression and are aberrantly expressed in cancer. We reported previously that all-trans-retinoic acid chemo-prevented carcinogenic transformation of human bronchial epithelial (HBE) cells through proteasomal degradation of cyclin D1. Retinoic acid is shown here to activate distinct mechanisms to regulate different D-type cyclins in HBE cell...
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Cycimns were originally defined as proteins which are synthesized in each cell cycle and destroyed at every mitosis. Cyclins were discovered by T. Hunt and students at the Marine Biological Laboratory, Woods Hole, MA, duningthe 1982 Physiology Course (1). They labeled eggs ofthe sea urchin Arbacia punctulata with [35S]methionine after fertilization and analyzed the temporal pattern of protein s...
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BACKGROUND Human papillomavirus (HPV) types 16 and 18 are associated with cervical carcinogenesis. This is possibly achieved through an interaction between HPV oncogenic proteins and some cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not well defined yet. METHODS We investigated 110 subjects (43 invasive squamous cell carcinoma (ISCC), 38 CIN III, 11 CIN II, 18 C...
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III. Cyclins and the cell cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 A. Major players in cell cycle control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 B. H u m a n cyclins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
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instance, is associated primarily with activation of S James M. Roberts Division of Basic Sciences phase whereas CDK1 primarily with mitosis. However, assays using defined peptides reveal only subtle differFred Hutchinson Cancer Research Center and Howard Hughes Medical Institute ences in substrate preference between CDK1 and CDK2 (Holmes and Solomon, 1996), and there is no compelling 1100 Fair...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2014
ISSN: 0923-7534
DOI: 10.1093/annonc/mdu301.3