Telaprevir to Boceprevir Switch Highlights Lack of Cross-Reactivity
نویسندگان
چکیده
منابع مشابه
Telaprevir to boceprevir switch highlights lack of cross-reactivity.
Hepatitis C viral protease inhibitors increase sustained virologic response rates compared to interferon and ribavirin but also add side effects. Telaprevir and boceprevir are structurally similar, and share cross-resistant mutations. This case report highlights successful management of telaprevir skin rash and anal discomfort by switching to boceprevir.
متن کاملEffects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir
AIMS The aim was to evaluate the effect of boceprevir and telaprevir on dolutegravir pharmacokinetics (PK); the effect of dolutegravir on boceprevir and telaprevir PK was assessed through comparison with historical data for each hepatitis C virus (HCV) drug's prescribing information alone. METHODS This was a single-centre, randomized, open-label, two-cohort, two-period, one-way study in healt...
متن کاملManaging Drug-Drug Interactions With Boceprevir and Telaprevir
The treatment of chronic hepatitis C virus (HCV) genotype 1 infection has been revolutionized by the introduction of direct-acting antiviral (DAA) agents (boceprevir and telaprevir) in combination with peginterferon and ribavirin. Although improved antiviral efficacy and shorter durations of therapy are anticipated, there are also potentially severe drug-drug interactions involving protease inh...
متن کاملTitle : Lack of Allergic Cross - Reactivity between Fluconazole and Voriconazole
Contact information: Angie Pinto Departments of Microbiology & Infectious Diseases Building 65, Royal Prince Alfred Hospital Missenden Road, Camperdown NSW 2050 Tel: 02 9515-8278 Fax: 02 9515-5235 Email: [email protected] CC EP TE D Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.11...
متن کاملHypersensitivity and cross-reactivity to cisplatin and carboplatin.
Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergenc...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2012
ISSN: 1537-6591,1058-4838
DOI: 10.1093/cid/cis960